Scientists explore new frontier in autoimmune disease treatment by resetting ‘rogue’ cells - PBS

Researchers are exploring innovative treatments for autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and lupus by focusing on reprogramming the dysfunctional immune systems of patients. Traditional therapies typically suppress immune responses but do not address the root causes, leading to a lifelong dependency on medications with significant side effects. The new experimental approaches, including CAR-T therapy originally developed for cancer treatment, aim to reset the immune system. Notably, early results have shown promise in restoring health to patients who have not responded to standard treatments. For example, a patient with lupus reported regaining her strength and being pain-free after undergoing CAR-T therapy. Other strategies include using engineered T cell therapies to calm immune reactions without the need for custom solutions. Although these therapies are still in early stages and come with risks, they represent a significant hope for a more effective treatment paradigm—an endeavor that experts believe may lead to improved outcomes and possibly even a cure for various autoimmune conditions in the next decade.