Scientists Trace Lupus to One of The World's Most Common Viruses - ScienceAlert

Recent research led by Stanford University scientists suggests that the Epstein-Barr virus (EBV), a common pathogen known for causing mononucleosis, might be responsible for nearly all cases of lupus, a chronic autoimmune disease. The study found that individuals with lupus have significantly higher rates of EBV-infected B cells, especially memory B cells, compared to healthy individuals. This deep infection may activate pro-inflammatory genes in these immune cells, potentially triggering the disease's debilitating symptoms. Despite the historical acknowledgment of lupus dating back to 850 CE, the exact cause has remained elusive, with various factors like genetics and hormonal issues previously implicated. The new findings offer a compelling unifying theory with viral origins, which could shed light on why individuals with EBV do not always develop lupus. Additionally, this research might have implications for other autoimmune diseases associated with EBV. The study presents a promising avenue for understanding lupus's pathology and could pave the way for targeted treatments focusing on the immune responses induced by EBV.